Spravato® (Esketamine): A Breakthrough for Treatment-Resistant Depression
FDA-Approved, Evidence-Based, and Compassionately Delivered
Schedule a Personalized ConsultationSpravato® (Esketamine) at Gravity Psychiatry & Wellness
Spravato® (esketamine) nasal spray is an FDA-approved medication specifically indicated for adults with treatment-resistant depression (TRD)—those who haven’t achieved adequate relief from at least two different antidepressants. Unlike traditional SSRIs or SNRIs that primarily modulate serotonin, Spravato® engages the NMDA receptor, potentially accelerating and enhancing antidepressant effects.
Expert Insight: In landmark trials published in the American Journal of Psychiatry and JAMA Psychiatry, esketamine therapy has shown promise in forming new neural pathways (synaptogenesis), contributing to faster and more durable improvements in mood for some patients.
A Comprehensive, Evidence-Backed Method
- Peer-Reviewed Studies: Trials like TRANSFORM-2 and SUSTAIN-1 show significant improvement in depressive symptoms compared to placebo.
- Rapid Relief Potential: Some individuals notice mood changes within the first few sessions, though results vary.
- Part of an Integrated Plan: Spravato® works best when combined with ongoing therapy, healthy coping strategies, and medication management.
Who Is It For?
Defining Treatment-Resistant Depression
TRD typically involves ongoing depression that persists despite trials of at least two different classes of antidepressants, taken at therapeutic doses and durations. Individuals may experience persistent sadness, hopelessness, or functional impairment. We also conduct thorough evaluations to rule out misdiagnoses such as bipolar disorder or unaddressed trauma.
Patient Suitability
- Screening & Consultation: We review medical history and discuss your full treatment journey.
- Medical and Psychiatric History: Additional lab work or assessments may be recommended.
- Shared Decision-Making: We present a balanced picture of potential benefits, risks, and alternatives.
The Spravato® Experience at Gravity Psychiatry & Wellness
Our process is designed to ensure safety, comfort, and optimal outcomes at every step.
Preparation & Education
We conduct a pre-treatment consultation to review the FDA’s Risk Evaluation and Mitigation Strategy (REMS) for Spravato®. You’ll receive guidance on how to self-administer the nasal spray and what to expect during the observation period.
Administration & Monitoring
- Relaxing Environment: A private, calming space is provided for administration, with warm lighting and comfortable seating.
- Self-Administration: Under direct supervision, you’ll administer Spravato® nasally.
- Observation: You’ll remain in our clinic for at least two hours for monitoring of vital signs and any side effects.
- Transportation: We require patients to arrange a safe ride home due to possible sedation or perception changes.
Follow-Up & Long-Term Support
Spravato® is typically administered twice weekly for four weeks, then tapered if improvement is noted. We pair it with talk therapy, lifestyle interventions, and continued medication management.
Safety, Side Effects & Regulatory Compliance
Potential Side Effects
- Dissociation or perceptual changes
- Dizziness, nausea, headache
- Increased blood pressure
A full list of side effects is detailed in the Spravato® Prescribing Information and the REMS Program. Our staff is trained to monitor and address any adverse reactions in real-time.
Boxed Warning & REMS Program
Spravato® carries a Boxed Warning for sedation, dissociation, and potential misuse. A certified facility (like ours) must administer it, ensuring strict patient monitoring and adherence to the REMS safety measures.
Clinical Evidence & References
Key Research Highlights
- TRANSFORM-2 Trial – Demonstrated significant symptom reduction in TRD patients (Journal of Psychiatric Research, 2019).
- SUSTAIN-1 Trial – Showed potential for relapse prevention with maintenance esketamine treatment (The Lancet Psychiatry, 2020).
- Real-World Data – Preliminary studies indicate promising remission rates outside of controlled trials.
Testimonials & Ethical Patient Stories
Ready to Explore Spravato®?
Contact our team for a thorough evaluation and personalized guidance on whether Spravato® might be right for you.
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